Publications

Selected published papers in last 8 years (in which J. Vachtenheim is a corresponding author):

Vachtenheim J, Borovanský J. "Transcription physiology" of pigment formation in melanocytes: central role of MITF. Exp Dermatol 19 (2010) 617-627.

Vachtenheim J, Ondrušová L, Borovanský J: SWI/SNF chromatin remodeling complex is critical for the expression of microphthalmia-associated transcription factor in melanoma cells. Biochem Biophys Res Commun 392 (2010) 454-459.

Sestáková B, Ondrušová L, Vachtenheim J.: Cell cycle inhibitor p21/ WAF1/CIP1 as a cofactor of MITF expression in melanoma cells. Pigment Cell & Melanoma Res. 23 (2010) 238-251.

Vachtenheim J, Ondrušová L.: MITF meets chromatin in melanoma. Kapitola v knize: In: New Developments in Chromatin Research (Eds. N. M. Simpson and V. J. Stewart), Nova Science Publishers Inc., New York, 2012, ISBN: 978-1-62081-816-9, pp. 105 - 122.

Vachtenheim J, Ondrušová L: MITF: A Critical Transcription Factor in Melanoma Transcriptional Regulatory Network. In: Recent Advances in the Biology, Therapy and Management of Melanoma. (Ed. L.M. Davids), InTech, Rijeka, Croatia, 2013, ISBN: 978-953-51-0976-1. pp.71-81.

Ondrušová L, Vachtenheim J, Réda J, Záková P, Benková K: MITF-Independent Pro-Survival Role of BRG1-Containing SWI/SNF Complex in Melanoma Cells. PLoS One 8 (2013) e54110, 1-10.

Vachtenheim J, Ondrušová L: Microphthalmia-associated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation. Exp Dermatol. 24 (2015) 481-484.

Vlčková K, Ondrušová L, Vachtenheim J, Réda J, Dundr P, Zadinová M, Žáková P and Poučková P: Survivin, a novel target of the Hedgehog/GLI signaling pathway in human tumor cells. Cell Death and Disease (2016), 7, e2048.

Vlčková K, Réda J, Ondrušová L, Krayem M, Ghanem G, Vachtenheim J: GLI inhibitor GANT61 kills melanoma cells and acts in synergy with obatoclax. J Int Oncol. 46 (2016) 953-960.

Vachtenheim J, Vlčková K: Insights into the regulation of survivin expression in tumors. Single Cell Biology 5 (2016), 1-5.

Vachtenheim J: The many roles of MITF in melanoma. Single Cell Biology 6 (2017), 1-4.

Vlčková K, Vachtenheim J, Réda J, Horák P, Ondrušová L: Inducibly decreased MITF levels do not affect proliferation and phenotype switching but reduce differentiation of melanoma cells. J Cell Mol Med. 22 (2018) 2240-2251.

Réda J, Vachtenheim J, Vlčková K, Horák P, Vachtenheim J Jr., Ondrušová L: Widespread expresion of Hedgehog pathway components in a large panel of human tumor cells and inhibition of tumor growth by GANT61: implications for cancer therapy. Int. J. Mol. Sci. 19 (2018). pii: E2682. doi: 10.3390/ijms19092682.

Vachtenheim J Jr., Lischke R, Vachtenheim J: Siva-1 emerges as a tissue-specific oncogene beyond its classic role of a proapoptotic gene. 11 (2018) 6361-6367. OncoTargets and Therapy.

Kreisingerová K, Ondrušová L, Horák P, Vachtenheim J: Význam aberantně aktivované dráhy Hedgehog/Gli pro nádorovou progresi. Klinická onkologie 33 (2020) 177-183. (In Czech) (remark: JV is not a corresponding author) 

Vachtenheim J Jr, Kodet R, Fischer O, Kolek V, Strizova Z, Ozaniak A, Simonek J, Stolz A, Pozniak J, Kolarik J, Svorcova M, Vachtenheim  J, Lischke R: Giant lung metastasis of a Spitzoid melanoma in a 24-year-old patient: a case report. Diagnostic Pathology (2020) 15:132. (7 pages)  (remark: JV is not a corresponding author) 

Vachtenheim J and Ondrušová L: Many Distinct Ways Lead to Drug Resistance in BRAF- and NRAS-Mutated Melanomas. Life. (Basel) (2021) 11:424. (13 pages)

Horák P, Kreisingerová K, Réda J, Ondrušová L, Balko J, Vachtenheim J Jr, Žáková P, Vachtenheim J: The Hedgehog/GLI signaling pathway activates transcription of Slug (Snail2) in melanoma cells. Oncol Rep (2023) 49(4): 75. (11 pages)

Selected older more important papers:

Yavuzer U, Keenan E, Lowings P, Vachtenheim J, Currie G and Goding CR: The Microphthalmia gene poduct interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription. Oncogene 10 (1995) 123-134.

Vachtenheim J, Horáková I and Novotná H: Hypomethylation of CCGG sites in the 3'-region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer. Cancer Res. 54 (1994) 1145-1148.

Vachtenheim J, Horáková I , Novotná H, Opálka P and Roubková H: Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung. Clin. Cancer Res. 1 (1995) 359-365.

Vachtenheim J, Novotna, H, and Ghanem, G: Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic MITF. J. Invest. Derm. 117 (2001) 1505-1511.