Hepatology and Gastroenterology
Laboratory for Research of
Liver Diseases and Heme Metabolism ÚLBLD is focused on special diagnostics of the liver diseases
(metabolic diseases, disorders of the heme biosynthetic and catabolic pathway).
The
Laboratory was originally established at the 1st Department of
Internal Medicine under the name Laboratory for Pathophysiology of Blood System
and Liver.
Routine
part of the Lab is focused on specialized liver examinations (determination of porphyrins
in the biological material, copper in the liver tissue, and/or bile acids).
Experimental
research covers a wide range of topics from the heme catabolic pathway
(including bilirubin toxicity as well as antioxidant properties),
atherosclerosis, pathogenesis of cancer diseases, or the role of glycosphingolipids
in the pathogenesis of liver diseases.
The
lab is fully equipped for almost any chromatography analyses, and has
established unique and ultrasensitive methods for determination of bilirubin in
tissues, bilirubin photoisomers or bilirubin oxidation products, as well as a
method (GC-RGD) for determination of carbon monoxide in biological tissues (in
collaboration with Stanford University).
02.01.2013 |
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zpět na Hepatology and gastroenterology